WT | G85R | G93A-Low | |
---|---|---|---|
Spike parameters | |||
n | 33 | 25 | 13 |
AP thr, mV | −35.1 ± 1.4 | −32.5 ± 1.3 | −35.8 ± 1.8 |
Peak amp, mV | 58.7 ± 1.4 | 61.6 ± 1.5 | 51.94 ± 2.79* |
Time to peak, ms | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.89 ± 0.07 |
Half-width, ms | 0.8 ± 0.3 | 0.9 ± 0.1 | 1.46 ± 0.13*** |
Max rise slope, mV/ms | 151.6 ± 7.4 | 163.1 ± 7.3 | 101.84 ± 8.00*** |
Max decay slope, mV/ms | −82.1 ± 4.6 | −77.0 ± 4.2 | −60.20 ± 5.87* |
AHP parameters | |||
n | 33 | 22 | 13 |
AHP peak amp, mV | −11.6 ± 0.5 | −12.2 ± 0.7 | −11.4 ± 0.6 |
AHP width, ms | 91.4 ± 6.5 | 100.2 ± 6.5 | 111.8 ± 11.4 |
Time to peak, ms | 15.1 ± 0.8 | 14.5 ± 1.0 | 16.2 ± 1.4 |
Half-width, ms | 45.4 ± 2.9 | 47.5 ± 2.3 | 53.3 ± 4.2 |
-
All values are means±SE. AP thr, threshold of action potential; peak amp, potential difference between maximum of spike potential and spike threshold; time to peak, time needed for potential to rise from spike threshold to maximum value; half-width, time spent by membrane potential >50% of the maximum amplitude of action potential; spike max rise slope, maximum slope on the depolarizing phase of spike potential; spike max decay slope, maximum slope on the repolarizing phase of spike potential; AHP peak amp, maximum value of post-spike after-hyperpolarization measured from spike threshold; AHP width, duration of post-spike after-hyperpolarization measured from end of spike potential to return of membrane potential to threshold value.
-
↵* P < 0.05,
-
↵*** P < 0.005, nonparametric permutation exact test.